Abstract:
Diabetes Mellitus is the most common non communicable chronic metabolic disease worldwide. Renal
complications are one of the major complications apart
from cardiovascular, neurological and retinal complications.
The objective of this study was to evaluate the effect
of type 2 diabetes mellitus duration on fasting plasma
glucose, serum creatinine and urinary microalbumin in
type 2 diabetics attending to Diabetic Centre at Teaching
Hospital Jaffna. A total of 98 patients diagnosed as type 2
diabetics without chronic kidney diseases were included.
Fasting plasma glucose (Glucose Oxidase method), serum
and urine creatinine (Jaffe Alkaline Picric Acid method)
and random urine albumin (Immunoturbidimetry method)
were estimated. The strength of correlation was determined
by Pearson correlation. The mean (±SD) fasting plasma
glucose, serum creatinine and urine albumin to creatinine
ratio were 136.17 (±53.92) mg/dL, 1.25 (±0.64) mg/dL and
49.31 (±102.64) mg/g creatinine respectively. The mean
(±SD) random urine creatinine, random urine albumin
and duration of diabetes mellitus were 1.21 (±0.80) g/L,
34.38 (±54.04) mg/L and 9.28 (±7.20) years respectively.
Out of 98 type 2 diabetics, 69 (70.41%), 25 (25.51%), and
4 (4.08%) had normoalbuminuria, microalbuminuria and
macroalbuminuria respectively. When the duration of
diabetes mellitus was increased, fasting plasma glucose
level, serum creatinine, random urine albumin and urine
albumin to creatinine ratio were gradually increased. But
random urine creatinine was gradually decreased with
the duration of diabetes mellitus. The longest duration
of diabetes mellitus was 13.57 (±9.93) years in the sub group of ≥201 mg/dL. The highest urine albumin to
creatinine ratio ≥61 mg/g was resulted in the mean (±SD)
duration of diabetes mellitus 14.27 (±7.70) years which
was the longest duration of diabetes mellitus. On applying
Pearson correlation, duration of diabetes mellitus showed
a weak positive correlations with fasting plasma glucose
(r = 0.251, p = 0.013) and serum creatinine (r = 0.097,
p = 0.340). Urine albumin to creatinine ratio showed
a weak positive correlation with duration of diabetes
mellitus which was statistically significant (r= 0.430, p=
0.000). This study revealed that FPG, serum creatinine
and albumin excretion were increased with the duration
of diabetes mellitus in type 2 diabetics.
