Pharmacy: Recent submissions

Now showing items 1-20 of 89

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors

Shifali, S.; Marina, D.; Zhang, D.; Tam, N.Y.; Pratheesh, M.; O’Connor, C.C.; Tumber, A.; Leung, I.K.H.; Ng, Y.M.; Leissing, T.M.; Sagheer, A.H.E.; Brown, T.; Salah, E.; Aik, W.S.; McDonough, M.A.; Schofield, C.J. (Journal of medicinal chemistry, 2025)

FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information ...
Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors

Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; Owen, C.D.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Salah, E.; Duarte, F.; Yang, H.; Rao, Z.; Walsh, M.A.; Schofield, C.J. (Royal society of Chemistry, 2021)

The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro ...
Antibacterial and antioxidant activity of different solvent extractions of leaves and bark of Erythrina variegata

Thuvaragan, S.; Gnanakarunyan, T.; Bandaranayaka, T.D.; Horshington, A.S.; Fernando, K.M.O. (University of Jaffna, 2024)

Introduction: Plant-based antimicrobials have been proven to be a promising treatment option with several advantages, including fewer side effects and highly diverse pharmacological activities due to secondary metabolites. ...
Evaluating the perception about the role of nuclear pharmacists among pharmacists in Northern Province, Sri Lanka

Praveena Priyadharshini, A.; Dhanushika Kumari, O.W.; Ranathunga, R.M.C.H.; Kalki, P.; Yoganathan, T.; Jeyanthan, M. (University of Jaffna, 2024)

Introduction: Nuclear pharmacy is a special field in pharmacy practice that requires specially trained nuclear pharmacists to handle radioactive substances. Due to ignorance, unfavourable opinions about nuclear pharmacy ...
The staining ability of natural flower extracts as alternative dyes for bacterial staining

Cafoor, F.N.; Najeem, F.N.; Haseeb, H.F.; Thillainathan, K.; Sivasinthujah, S.; Gnanakarunyan, T. (University of Jaffna, 2024)

Introduction: Gram staining is used as a routine stain in bacteriology. Synthetic stains are commonly used for Gram staining which were reported to cause adverse effects to the environment and user. The use of natural ...
In-vitro anti-fungal activity of different extracts of leaf of Vateria copallifera

Saara, F.; Aamila, N.; Jifla, J.; Sivasinthujah, S.; Jeyaseelan, E.C. (University of Jaffna, 2024)

Introduction: The increased prevalence of fungal infections is attributable to an increase in the number of immunocompromised hosts. Bioactive compounds present in the plants are used as models for the synthesis of medicinal ...
In-vitro evaluation of antioxidant property of different parts of Momordica balsamina using ferric reduction antioxidant assay

Amirthavarshini, A.; Abisha, S.; Nushrath, K.L.F.; Sivasinthujah, S.; Srikaran, R. (University of Jaffna, 2024)

Introduction: Antioxidants are substances that can inhibit or delay unwanted reactions of oxidation through one or more mechanisms. Antioxidant phytochemicals found in medicinal plants could play an important role in the ...
Evaluation of total antioxidant activity of deproteinized and nondeproteinized polysaccharides extracted from leaves of Hemidesmus indicus (Nannari)

Salini, N.; Aberame, S.; Piriyanka, N.; Sivasinthujah, S.; Senthilnanthanan, M. (University of Jaffna, 2024)

Introduction: Recently, polysaccharides derived from natural products have attained considerable attention as potent in vivo and in vitro antioxidants. Hemidesmus indicus is a plant valued for its diverse uses in traditional ...
Physicochemical and Phytochemical screening of 'Neerizhivu Chooranam 1' used for Diabetes Mellitus in Northern Province, Sri Lanka

Merin Dinushiya, J.; Nilanusha, S.; Sugansika, M.; Sivasinthujah, S.; Sivarangini, S.; Ravimannan, N. (University of Jaffna, 2024)

Introduction: Neerizhivu Chooranam 1 is a polyherbal drug, mainly consists of Terminalia chebula, Embilica officianalis and Murraya koenigiiand it is called as Mathumaeha Choornam. This medication is especially used in ...
Antibacterial activity of acetone fractions of the root of Vateria copallifera against Staphylococcus aureus and Escherichia coli

Nirubini, A.S.; Ajeetha, J.; Sivasinthujah, S.; Gnanakarunyan, T.J.; Srikaran, R. (University of Ruhuna, 2024)

Vateria copallifera is an endemic plant to Sri Lanka, and it is used traditionally for the treatment of wound healing. Therefore, this study focused on the antibacterial activity of fractionations obtained from the acetone ...
Investigation of antioxidant activity in leaf extract of Argyreia pomacea (Manpanchan)

Yogarasa, L.; Srikokulan, S.; Senthilnanthanan, M. (University of Ruhuna, 2024)

Oxidative stress is a fundamental process underlying various human diseases. Antioxidants are substances that significantly delay or inhibit the oxidation of substrates. Plants and plant products are natural sources of ...
Invitro antioxidant activity of methanolic extract of selected polyherbal drug used in Diabetes Mellitus in Northern Province, Sri Lanka.

Merin Dinushiya, J.; Nilanusha, S.; Sugansika, M.; Sivasinthujah, S.; Sivarangini, S. (University of Sri Jayewardenepura, 2024)

Background: The antioxidants are mainly involved in preventing the oxidative stress and these are used in diabetes mellitus patients in preventing the further damage to the beta cells caused by the radicals formed due ...
In vitro evaluation of antibacterial activity of leaf extracts of Atalantia ceylanica

Uthpala, R.M.; Wijewardhana, B.A.D.I.M.; Pemadasa, D.A.I.S.; Sivasinthujah, S.; Gnanakarunyan, T.J. (University of Sri Jayewardenepura, 2024)

Background: Atalantica ceylanica plant has been recognized as a multi-purpose medicinal plant which is widely applied to treat respiratory tract infections. Recently, this plant has gained popularity among people for ...
In vitro antioxidant activity of polysaccharide in Hemidesmus indicus (Nannari) leaves

Salini, N.; Aberame, S.; Piriyanka, N.; Sivasinthujah, S.; Senthilnanthanan, M. (University of Sri Jayewardenepura, 2024)

Background: Polysaccharides are potent natural antioxidants which can greatly slow down or prevent substrate oxidation. Hemidesmus indicus has been recognized in traditional medicine system for its medicinal attributes ...
Antibacterial activity of polysaccharides extracted from the root of Premna serratifolia (Wind killer)

Ginthujah, V.; Jayapria, S.; Sivasinthujah, S.; Tharmila, C.J.; Srithevi, S.; Thirtsha, G. (University of Sri Jayewardenepura, 2024)

Background: Emerging infectious diseases, especially skin infections pose significant threats to human health. Conventional antibiotics encounter challenges of antibiotic resistance and side effects, necessitating the ...
Physicochemical and preliminary phytochemical analysis of different brands ofHingwashtak churna; a polyherbal medicine in Sri Lanka

Dassanayaka, G. G.; Sivasinthujah, S.; Christy Jeyaseelan, T. (Ayurveda Sahiti Prabha, 2024)

Hingwashtak churna is a polyherbal medicine, used to treat gastrointestinal diseases like gastric ulcers, bloating, acidity, and joint disease. The quality evaluation of hingwashtak churna is needed for its ...
Evaluation of antibacterial activity of root extracts of herbal plant, Leucas zeylanica

Rupasinghe, K. M. U. K.; Patabendige, I. W. L.; Pathirana, U. P. P. S.; Srikokulan, S.; Gnanakarunyan, T. J.; Srikaran, R. (University of Jaffna, 2023)

Introduction: Leucas zeylanica used to treat inflammatory conditions, gout and microbial infections such as wounds, sores, itches, vertigo, anorexia, acute and chronic dyspepsia and flatulence in Sri Lankan traditional ...
Formulation and characterization of essential oils based antibacterial hand sanitizer gels

Diviyagahage, C.M.; Thuvaragan, S.; Gnanakarunyan, T.J.; Srikaran, R. (Pharmaceutical Society of Sri Lanka, 2021)

Purpose: The usage of herbal-based antibacterial sanitizers is increasing, and they have considerably shown fewer side-effects than sanitizers with synthetic compounds. In the present study, essential oils obtained from ...
Comparative Evaluation of Metformin Hydrochloride Brands Available in Sri Lanka

Lakmali, E.M.M.S.; Thanujah, M.; Thuvaragan, S.; Kuruppu, K.D.A. (KDU, 2021)

Metformin, being noteworthy, is used in the management of Type 2 Diabetes. It is available in different brands in Sri Lanka. Several studies have shown that different brands of the drug varied qualities, which could ...
Comparative evaluation of antibacterial activity of solvent fractions and essential oil of Cyperus rotundus L. rhizomes

Thuvaragan, S.; Nishadini, N.V.C.; Gnanakarunyan, T.; Srikaran, R. (BioMed Research Publishers, 2021)

Cyperus rotundus L. belongs to the family Cyperaceae. It is used to treat constipation, stomach disorders, dysmenorrhea, skin diseases, wounds, leprosy, fever, etc., in indigenous medicine. Also, they are used to treat ...

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