• Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB 

  Simranjeet, K.; Pratheesh, M.; Samanpreet, K.; Yingqi, L.; Eidarus, S.; Dong, Z.; Shifali, S.; Christopher, J.S.; Wei Shen, A. (Oxford University Press, 2025)

  N6-Methyladenosine (m6A) is a prevalent post-transcriptional modification in eukaryotic messenger RNA. Two cancer-linked human Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenases, the fat mass and obesity associated-protein ...
• Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors 

  Shishodia, S.; Marina, D.; Zhang, D.; Tam, N.Y.; Pratheesh, M.; Clunie-O’Connor, C.; Tumber, A.; Leung, I.K. H.; Min Ng, Y.; Leissing, T.M.; El-Sagheer, A.H.; Salah, E.; Brown, T.; Shen Aik, W.; McDonough, M.A.; Christopher, J.S. (American Chemical Society, 2021)

  FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information ...
• Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors 

  Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; David Owen, C.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Zihe Rao; Zihe Rao, M.A.; Schofield, C.J. (The Royal Society of Chemistry, 2021)

  The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro ...
• Ethnobotany of medicinal plants in treating diabetes Mellitus among indigenous medical practitioners in jaffna, Sri lanka 

  Niluka, N.; Sathya, S.; Srikokulan, S. (University of Peradeniya, 2023)

  Diabetes mellitus (DM) is a non-communicable metabolic disease which is caused due to inappropriate elevation of blood glucose levels due to the impairment of insulin synthesis or utilization. The usage of medicinal ...
• An Ethnobotanical Survey of Medicinal Plants Used by Diabetes Patients Attending the Teaching Hospital, Jaffna, Sri Lanka 

  Niluka, N.; Sathya, S.; Sivasinthujah, S. (Ceylon Journal of Science, 2024)

  The scope of this study is to describe the ethnobotany of medicinal plants used in the management of diabetes mellitus (DM) among diabetic patients attending the Teaching Hospital, Jaffna. A cross-sectional descriptive ...
• Exploring urinary biomarkers for the diagnosis of diabetic and hypertensive chronic kidney disease: A promising pilot study 

  Saseevan, S.; Nishanthi, N.; Sanath, R.; Magana-Arachchi, D. (Indian Journal of Experimental Biology, 2024)

  In the current clinical setting, conventional serum biomarkers such as serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) have several lapses in chronic kidney disease (CKD) diagnosis. Diagnosing CKD ...
• RNA extraction from urine sediment: A cost-effective protocol for gene expression analysis in renal pathology. 

  Saseevan, S.; Rajapakse, S.; Magana-Arachchi, D.N. (Ceylon Journal of Science, 2020)

  Urine is an appropriate choice of specimen to study the biomarkers for metabolic and renal disorders because it is readily available with less harm to the patients. However, RNA extraction from voided urine is challenging ...
• Culturable bacterial pathogens in midstream urine of chronic kidney disease patients in Vavuniya, Sri Lanka: A preliminary study 

  Jayalath, J.M.S.D.; Saseevan, S.; Perera, W.A.K.; Magana-Arachchi, D.N. (Young Scientists’ Association, National Institute of Fundamental Studies, 2021)

  Background: Contribution of the midstream urine microbiome to chronic kidney disease (CKD) is clinically relevant, yet it’s understudied. Objectives: To identify bacteria from midstream urine of CKD patients with comorbidities ...
• Urinary annexin A3 and neutrophil gelatinase-associated lipocalin: Potential diagnostic biomarkers for diabetic nephropathy 

  Saseevan, S.; Rajapakse, S.; Magana-Arachchi, D.N. (Sri Lanka Association for the Advancement of Science, 2022)

  Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus. Tubular lesions initially characterize DN before the glomerular injury. Therefore, albuminuria is not sufficient to diagnose DN. Urinary ...
• The role of clinicopathological factors on the adoption of Lipocalin 2 (LCN2) gene as a renal biomarker for chronic kidney disease 

  Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana Arachchi, D.N. (Young Scientists’ Association, National Institute of Fundamental Studies, 2023)

  The Lipocalin 2 (LCN2) gene has been identified as a tubular injury-related renal biomarker in chronic kidney disease (CKD). However, the findings remain equivocal as its regulations could be influenced by clinicopathological ...
• Urinary Peptidase Inhibitor 3 could be a potential biomarker for diabetic and hypertensive nephropathy 

  Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana Arachchi, D.N. (Sri Lanka Medical Association, 2023)

  Introduction Peptidase Inhibitor 3 (PI3) gene, known as elafin is a protein inhibitor. Its expression is predominantly found in kidney tubules and causes a cytokine-mediated inflammatory response in kidney injury. Obje ...
• Investigation of Microbial Quality of Air During the Transboundary Haze in Kandy, Sri Lanka: December 2022 Update 

  Saseevan, S.; Gunathilaka, H.M.S.A.T.; Jayaweera, Y.U.; Udangamuwa, R.H.M.S.Y. (Sabaragamuwa University of Sri Lanka, 2023)

  Sri Lanka experienced a transboundary haze event in December 2022. The air quality index changed significantly during this period. This study aims to determine the impact of haze events on bacterial consortia and the ...
• Optimization of total RNA extraction from human urinary sediment 

  Saseevan, S.; Magana-Arachchi, D.N.; Rajapakse, S. (Postgraduate Institute of Science Research Congress, Sri Lanka, 2021)

  Urine is the best choice to identify biomarkers for metabolic and renal disorders because it is readily available, and samples can be obtained non-invasively from patients. However, RNA isolation from voided urine is ...
• Comparison of dipstick and manual methods for urine ph, sugar and protein in patients attending out-patient department Laboratory, teaching hospital, jaffna, sri lanka 

  Saseevan, S.; Vithegi, K.; Balakumar, S.; Surenthirakumaran, R. (General Sir John Kotelawala Defence University Sri Lanka, 2017)

  Dipstick urinalysis, a rapid diagnostic method is routinely used in clinical laboratories needs preserved samples to provide accurate results when test is not performed by two hours. This study compared dipstick ...
• Diversity of midstream urinary bacteria in chronic kidney Disease patients: a preliminary culture-based study 

  Saseevan, S; Bamunuarachchi, B.A.S.S.; Jayalath, J.M.S.D.; Nishanthi, W.A.A.G.N.; Magana-Arachchi, D.N. (University of Peradeniya, 2020)

  Introduction: Chronic kidney disease (CKD) is a global disease. Diabetes and hypertension are major risk factors for CKD, while bacterial colonization in the urinary system causes rapid disease progression. Objectives: ...
• Upregulation of the olfactomedin 4 gene enables the disease progression in chronic kidney disease patients 

  Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana-Arachchi, D.N. (University of Sri Jayewardenepura, 2022)

  Background: Olfactomedin 4 is a glycoprotein encoded by the gene, OLFM4 and found in various tissues including pancreatic β-cells. It involves various pathways of innate immunity, inflammation, and malignancies. However, ...
• Evaluation of nutrient agar and Antibiotic Assay Medium 1 as cost-effective alternatives to Mueller-Hinton agar for antibiotic sensitivity testing 

  Vidana, P. H.; Semasinghe, T.; Kumarapperuma, M.; Ganakarynyan, T.; Saseevan, S. (University of Jaffna, 2024)

  The antibiotic sensitivity test (ABST) is a crucial tool in clinical microbiology for determining the most effective antibiotic to treat infections. Though Mueller-Hinton Agar (MHA) is the standard culture medium used for ...
• Detection of is6110 (insertion sequence) in serum of Tuberculosis patients reported to kandy chest clinic 

  Saseevan, S.; Karunathilaka, R.I.S.; Bandara, W.R.U.A.; Madegedara, D.; Arachchi, D. N. M. (South Eastern University of Sri Lanka, 2023)

  Tuberculosis (TB) remains a global health challenge, necessitating the development of more sensitive and non-invasive diagnostic tools. This preliminary cross-sectional study explores the potential of detecting the IS6110 ...
• Knowledge and Factors Influencing Self-care Behaviors of Arteriovenous Fistula among CKD Patients in Hemodialysis Units in the Jaffna Peninsula 

  Appuhamy, K.D.S.M.; Kaushalya, L.S.; Jegapragash, V.; Thangaraja, B.R. (University of Jaffna, 2024)

  Chronic Kidney Disease (CKD) is a non-communicable disease, which causes progressive kidney damage and serious complications. Hemodialysis is a management method currently used worldwide to reduce or control symptoms ...
• Factors associated with knowledge on blood donation among the undergraduates of University of Jaffna 

  Tharmini, N.; Vanavan, V.; Jegapragash, V.; Hettiarachchi, A.N. (University of Jaffna, 2024)

  Blood is a vital and life-saving substance in medical emergencies. To ensure a steady supply of safe blood and blood products, a sufficient number of self-directed blood donors from the young population must be encouraged. ...

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