• Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors 

  Shishodia, S.; Marina, D.; Zhang, D.; Tam, N.Y.; Pratheesh, M.; Clunie-O’Connor, C.; Tumber, A.; Leung, I.K. H.; Min Ng, Y.; Leissing, T.M.; El-Sagheer, A.H.; Salah, E.; Brown, T.; Shen Aik, W.; McDonough, M.A.; Christopher, J.S. (American Chemical Society, 2021)

  FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information ...
• Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors 

  Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; David Owen, C.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Zihe Rao; Zihe Rao, M.A.; Schofield, C.J. (The Royal Society of Chemistry, 2021)

  The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro ...
• Ethnobotany of medicinal plants in treating diabetes Mellitus among indigenous medical practitioners in jaffna, Sri lanka 

  Niluka, N.; Sathya, S.; Srikokulan, S. (University of Peradeniya, 2023)

  Diabetes mellitus (DM) is a non-communicable metabolic disease which is caused due to inappropriate elevation of blood glucose levels due to the impairment of insulin synthesis or utilization. The usage of medicinal ...
• An Ethnobotanical Survey of Medicinal Plants Used by Diabetes Patients Attending the Teaching Hospital, Jaffna, Sri Lanka 

  Niluka, N.; Sathya, S.; Sivasinthujah, S. (Ceylon Journal of Science, 2024)

  The scope of this study is to describe the ethnobotany of medicinal plants used in the management of diabetes mellitus (DM) among diabetic patients attending the Teaching Hospital, Jaffna. A cross-sectional descriptive ...
• Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors 

  Shifali, S.; Marina, D.; Zhang, D.; Tam, N.Y.; Pratheesh, M.; O’Connor, C.C.; Tumber, A.; Leung, I.K.H.; Ng, Y.M.; Leissing, T.M.; Sagheer, A.H.E.; Brown, T.; Salah, E.; Aik, W.S.; McDonough, M.A.; Schofield, C.J. (Journal of medicinal chemistry, 2025)

  FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information ...
• Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors 

  Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; Owen, C.D.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Salah, E.; Duarte, F.; Yang, H.; Rao, Z.; Walsh, M.A.; Schofield, C.J. (Royal society of Chemistry, 2021)

  The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro ...
• Antibacterial and antioxidant activity of different solvent extractions of leaves and bark of Erythrina variegata 

  Thuvaragan, S.; Gnanakarunyan, T.; Bandaranayaka, T.D.; Horshington, A.S.; Fernando, K.M.O. (University of Jaffna, 2024)

  Introduction: Plant-based antimicrobials have been proven to be a promising treatment option with several advantages, including fewer side effects and highly diverse pharmacological activities due to secondary metabolites. ...
• Evaluating the perception about the role of nuclear pharmacists among pharmacists in Northern Province, Sri Lanka 

  Praveena Priyadharshini, A.; Dhanushika Kumari, O.W.; Ranathunga, R.M.C.H.; Kalki, P.; Yoganathan, T.; Jeyanthan, M. (University of Jaffna, 2024)

  Introduction: Nuclear pharmacy is a special field in pharmacy practice that requires specially trained nuclear pharmacists to handle radioactive substances. Due to ignorance, unfavourable opinions about nuclear pharmacy ...
• The staining ability of natural flower extracts as alternative dyes for bacterial staining 

  Cafoor, F.N.; Najeem, F.N.; Haseeb, H.F.; Thillainathan, K.; Sivasinthujah, S.; Gnanakarunyan, T. (University of Jaffna, 2024)

  Introduction: Gram staining is used as a routine stain in bacteriology. Synthetic stains are commonly used for Gram staining which were reported to cause adverse effects to the environment and user. The use of natural ...
• In-vitro anti-fungal activity of different extracts of leaf of Vateria copallifera 

  Saara, F.; Aamila, N.; Jifla, J.; Sivasinthujah, S.; Jeyaseelan, E.C. (University of Jaffna, 2024)

  Introduction: The increased prevalence of fungal infections is attributable to an increase in the number of immunocompromised hosts. Bioactive compounds present in the plants are used as models for the synthesis of medicinal ...
• In-vitro evaluation of antioxidant property of different parts of Momordica balsamina using ferric reduction antioxidant assay 

  Amirthavarshini, A.; Abisha, S.; Nushrath, K.L.F.; Sivasinthujah, S.; Srikaran, R. (University of Jaffna, 2024)

  Introduction: Antioxidants are substances that can inhibit or delay unwanted reactions of oxidation through one or more mechanisms. Antioxidant phytochemicals found in medicinal plants could play an important role in the ...
• Evaluation of total antioxidant activity of deproteinized and nondeproteinized polysaccharides extracted from leaves of Hemidesmus indicus (Nannari) 

  Salini, N.; Aberame, S.; Piriyanka, N.; Sivasinthujah, S.; Senthilnanthanan, M. (University of Jaffna, 2024)

  Introduction: Recently, polysaccharides derived from natural products have attained considerable attention as potent in vivo and in vitro antioxidants. Hemidesmus indicus is a plant valued for its diverse uses in traditional ...
• Physicochemical and Phytochemical screening of 'Neerizhivu Chooranam 1' used for Diabetes Mellitus in Northern Province, Sri Lanka 

  Merin Dinushiya, J.; Nilanusha, S.; Sugansika, M.; Sivasinthujah, S.; Sivarangini, S.; Ravimannan, N. (University of Jaffna, 2024)

  Introduction: Neerizhivu Chooranam 1 is a polyherbal drug, mainly consists of Terminalia chebula, Embilica officianalis and Murraya koenigiiand it is called as Mathumaeha Choornam. This medication is especially used in ...
• Antibacterial activity of acetone fractions of the root of Vateria copallifera against Staphylococcus aureus and Escherichia coli 

  Nirubini, A.S.; Ajeetha, J.; Sivasinthujah, S.; Gnanakarunyan, T.J.; Srikaran, R. (University of Ruhuna, 2024)

  Vateria copallifera is an endemic plant to Sri Lanka, and it is used traditionally for the treatment of wound healing. Therefore, this study focused on the antibacterial activity of fractionations obtained from the acetone ...
• Investigation of antioxidant activity in leaf extract of Argyreia pomacea (Manpanchan) 

  Yogarasa, L.; Srikokulan, S.; Senthilnanthanan, M. (University of Ruhuna, 2024)

  Oxidative stress is a fundamental process underlying various human diseases. Antioxidants are substances that significantly delay or inhibit the oxidation of substrates. Plants and plant products are natural sources of ...
• Invitro antioxidant activity of methanolic extract of selected polyherbal drug used in Diabetes Mellitus in Northern Province, Sri Lanka. 

  Merin Dinushiya, J.; Nilanusha, S.; Sugansika, M.; Sivasinthujah, S.; Sivarangini, S. (University of Sri Jayewardenepura, 2024)

  Background: The antioxidants are mainly involved in preventing the oxidative stress and these are used in diabetes mellitus patients in preventing the further damage to the beta cells caused by the radicals formed due ...
• In vitro evaluation of antibacterial activity of leaf extracts of Atalantia ceylanica 

  Uthpala, R.M.; Wijewardhana, B.A.D.I.M.; Pemadasa, D.A.I.S.; Sivasinthujah, S.; Gnanakarunyan, T.J. (University of Sri Jayewardenepura, 2024)

  Background: Atalantica ceylanica plant has been recognized as a multi-purpose medicinal plant which is widely applied to treat respiratory tract infections. Recently, this plant has gained popularity among people for ...
• In vitro antioxidant activity of polysaccharide in Hemidesmus indicus (Nannari) leaves 

  Salini, N.; Aberame, S.; Piriyanka, N.; Sivasinthujah, S.; Senthilnanthanan, M. (University of Sri Jayewardenepura, 2024)

  Background: Polysaccharides are potent natural antioxidants which can greatly slow down or prevent substrate oxidation. Hemidesmus indicus has been recognized in traditional medicine system for its medicinal attributes ...
• Antibacterial activity of polysaccharides extracted from the root of Premna serratifolia (Wind killer) 

  Ginthujah, V.; Jayapria, S.; Sivasinthujah, S.; Tharmila, C.J.; Srithevi, S.; Thirtsha, G. (University of Sri Jayewardenepura, 2024)

  Background: Emerging infectious diseases, especially skin infections pose significant threats to human health. Conventional antibiotics encounter challenges of antibiotic resistance and side effects, necessitating the ...
• Physicochemical and preliminary phytochemical analysis of different brands ofHingwashtak churna; a polyherbal medicine in Sri Lanka 

  Dassanayaka, G. G.; Sivasinthujah, S.; Christy Jeyaseelan, T. (Ayurveda Sahiti Prabha, 2024)

  Hingwashtak churna is a polyherbal medicine, used to treat gastrointestinal diseases like gastric ulcers, bloating, acidity, and joint disease. The quality evaluation of hingwashtak churna is needed for its ...

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