Abstract:
The ruthenium complexes were synthesized from ruthenium(III) metal precursors and
thiosemicarbazone ligands by ligand exchange reactions. The structural features of the synthesized
complexes were studied by various physico-chemical and spectroscopic techniques. In all the complexes
studied, the Schiff bases act as bidentate ligands. The efficiency of the ruthenium(III) complexes towards
the biomolecules, the interaction between DNA/BSA was studied. In addition, the cytotoxic properties of
the complexes were evaluated against a panel of bacteria and the efficiency of complexes to arrest the
growth of HeLa and MCF-7 tumour cell lines have been studied along with cell viability test under in vitro
conditions. The results showed a dose dependent anti-proliferative effect, thus indicating the biological
significance of the complexes. Moreover, the complexes were examined the oxidation inhibition property
against the DPPH and OH radicals.
