Abstract:
Apart from the biomaterial selection, the geometrical & pore structure of bone scaffolds, their
mechanical and bio-fluid properties play important criteria in the design of 3D porous scaffolds for bone
tissue regeneration. The joint multi-fields such as computer aided design (CAD), finite element analysis
(FEA) and computational fluid dynamics (CFD) will be applied for the design of bone scaffolds. The
motivation of this research is to predict the mechanical and fluid properties of triply periodic minimal
surface (TPMS) based bone scaffolds for different geometrical and material parameters. TPMS scaffold
structure using CAD provides high surface to volume ratio, high permeability and interconnections with
merits of aiding cell migration. The FEA and CFD help to improve the design of bone scaffolds and predict
the behaviour of complex structures for efficient bone tissue formation in mechanical loading, compression
and fluid perfusion. Further, an integrated model (Mechanical & Monte Carlo models) will be applied for
simulation of scaffolds degradation and a model to simulate angiogenesis & tissue regeneration in the
scaffolds will also be created.
