Abstract:
Diabetic Foot Ulcer is one of the traumatic complications that develop due to impaired glycemic
control and increased plantar pressure. Addressing the issues of necrosis, ischemia, inflammation, infection
and peripheral arterial disease is important to attain a wholesome treatment, depending on the prognostic
stage in DFU. PAD leading to uneven plantar pressure can be better treated by off-loading techniques. It is
essential to arrest further aggravation of the ulcer, attain ideal wound closure and prevent recurrence.
Though various treatment methods have been employed from the past, search for novel dressings are still
on the rise, since prevalence of ulcer varies between individual patients and their adapted life style. This
review emphasizes the contribution of various natural and synthetic polymeric materials, composite forms
and the role of incorporating signalling molecules such as growth factors, cytokines, chemokines, their
properties and delivery mechanisms as standard wound dressing in diabetic ulcers. Through extensive
study on the occurrence, prognosis, severity and the cellular responses observed at the site, strategic
management to alleviate the conditions of the challenging DFU could be made possible.
