Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors

Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; David Owen, C.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Zihe Rao; Zihe Rao, M.A.; Schofield, C.J.

dc.contributor.author	Malla, T.R.
dc.contributor.author	Tumber, A.
dc.contributor.author	John, T.
dc.contributor.author	Brewitz, L.
dc.contributor.author	Strain-Damerell, C.
dc.contributor.author	David Owen, C.
dc.contributor.author	Lukacik, P.
dc.contributor.author	Henry Chan, H.T.
dc.contributor.author	Pratheesh, M.
dc.contributor.author	Zihe Rao
dc.contributor.author	Zihe Rao, M.A.
dc.contributor.author	Schofield, C.J.
dc.date.accessioned	2025-06-09T08:21:34Z
dc.date.available	2025-06-09T08:21:34Z
dc.date.issued	2021
dc.identifier.issn	1359-7345
dc.identifier.uri	http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11357
dc.description.abstract	The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some b-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.	en_US
dc.language.iso	en	en_US
dc.publisher	The Royal Society of Chemistry	en_US
dc.title	Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors	en_US
dc.type	Article	en_US