Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors

Malla, T.R.; Tumber, A.; John, T.; Brewitz, L.; Strain-Damerell, C.; Owen, C.D.; Lukacik, P.; Henry Chan, H.T.; Pratheesh, M.; Salah, E.; Duarte, F.; Yang, H.; Rao, Z.; Walsh, M.A.; Schofield, C.J.

dc.contributor.author	Malla, T.R.
dc.contributor.author	Tumber, A.
dc.contributor.author	John, T.
dc.contributor.author	Brewitz, L.
dc.contributor.author	Strain-Damerell, C.
dc.contributor.author	Owen, C.D.
dc.contributor.author	Lukacik, P.
dc.contributor.author	Henry Chan, H.T.
dc.contributor.author	Pratheesh, M.
dc.contributor.author	Salah, E.
dc.contributor.author	Duarte, F.
dc.contributor.author	Yang, H.
dc.contributor.author	Rao, Z.
dc.contributor.author	Walsh, M.A.
dc.contributor.author	Schofield, C.J.
dc.date.accessioned	2025-04-21T03:27:58Z
dc.date.available	2025-04-21T03:27:58Z
dc.date.issued	2021
dc.identifier.uri	http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11209
dc.description.abstract	The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some b-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal society of Chemistry	en_US
dc.title	Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors	en_US
dc.type	Article	en_US