Medical Laboratory Sciences: Recent submissions

Now showing items 1-20 of 33

Exploring urinary biomarkers for the diagnosis of diabetic and hypertensive chronic kidney disease: A promising pilot study

Saseevan, S.; Nishanthi, N.; Sanath, R.; Magana-Arachchi, D. (Indian Journal of Experimental Biology, 2024)

In the current clinical setting, conventional serum biomarkers such as serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) have several lapses in chronic kidney disease (CKD) diagnosis. Diagnosing CKD ...
RNA extraction from urine sediment: A cost-effective protocol for gene expression analysis in renal pathology.

Saseevan, S.; Rajapakse, S.; Magana-Arachchi, D.N. (Ceylon Journal of Science, 2020)

Urine is an appropriate choice of specimen to study the biomarkers for metabolic and renal disorders because it is readily available with less harm to the patients. However, RNA extraction from voided urine is challenging ...
Culturable bacterial pathogens in midstream urine of chronic kidney disease patients in Vavuniya, Sri Lanka: A preliminary study

Jayalath, J.M.S.D.; Saseevan, S.; Perera, W.A.K.; Magana-Arachchi, D.N. (Young Scientists’ Association, National Institute of Fundamental Studies, 2021)

Background: Contribution of the midstream urine microbiome to chronic kidney disease (CKD) is clinically relevant, yet it’s understudied. Objectives: To identify bacteria from midstream urine of CKD patients with comorbidities ...
Urinary annexin A3 and neutrophil gelatinase-associated lipocalin: Potential diagnostic biomarkers for diabetic nephropathy

Saseevan, S.; Rajapakse, S.; Magana-Arachchi, D.N. (Sri Lanka Association for the Advancement of Science, 2022)

Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus. Tubular lesions initially characterize DN before the glomerular injury. Therefore, albuminuria is not sufficient to diagnose DN. Urinary ...
The role of clinicopathological factors on the adoption of Lipocalin 2 (LCN2) gene as a renal biomarker for chronic kidney disease

Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana Arachchi, D.N. (Young Scientists’ Association, National Institute of Fundamental Studies, 2023)

The Lipocalin 2 (LCN2) gene has been identified as a tubular injury-related renal biomarker in chronic kidney disease (CKD). However, the findings remain equivocal as its regulations could be influenced by clinicopathological ...
Urinary Peptidase Inhibitor 3 could be a potential biomarker for diabetic and hypertensive nephropathy

Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana Arachchi, D.N. (Sri Lanka Medical Association, 2023)

Introduction Peptidase Inhibitor 3 (PI3) gene, known as elafin is a protein inhibitor. Its expression is predominantly found in kidney tubules and causes a cytokine-mediated inflammatory response in kidney injury. Obje ...
Investigation of Microbial Quality of Air During the Transboundary Haze in Kandy, Sri Lanka: December 2022 Update

Saseevan, S.; Gunathilaka, H.M.S.A.T.; Jayaweera, Y.U.; Udangamuwa, R.H.M.S.Y. (Sabaragamuwa University of Sri Lanka, 2023)

Sri Lanka experienced a transboundary haze event in December 2022. The air quality index changed significantly during this period. This study aims to determine the impact of haze events on bacterial consortia and the ...
Optimization of total RNA extraction from human urinary sediment

Saseevan, S.; Magana-Arachchi, D.N.; Rajapakse, S. (Postgraduate Institute of Science Research Congress, Sri Lanka, 2021)

Urine is the best choice to identify biomarkers for metabolic and renal disorders because it is readily available, and samples can be obtained non-invasively from patients. However, RNA isolation from voided urine is ...
Comparison of dipstick and manual methods for urine ph, sugar and protein in patients attending out-patient department Laboratory, teaching hospital, jaffna, sri lanka

Saseevan, S.; Vithegi, K.; Balakumar, S.; Surenthirakumaran, R. (General Sir John Kotelawala Defence University Sri Lanka, 2017)

Dipstick urinalysis, a rapid diagnostic method is routinely used in clinical laboratories needs preserved samples to provide accurate results when test is not performed by two hours. This study compared dipstick ...
Diversity of midstream urinary bacteria in chronic kidney Disease patients: a preliminary culture-based study

Saseevan, S; Bamunuarachchi, B.A.S.S.; Jayalath, J.M.S.D.; Nishanthi, W.A.A.G.N.; Magana-Arachchi, D.N. (University of Peradeniya, 2020)

Introduction: Chronic kidney disease (CKD) is a global disease. Diabetes and hypertension are major risk factors for CKD, while bacterial colonization in the urinary system causes rapid disease progression. Objectives: ...
Upregulation of the olfactomedin 4 gene enables the disease progression in chronic kidney disease patients

Saseevan, S.; Nishanthi, W.A.A.G.N.; Rajapakse, S.; Magana-Arachchi, D.N. (University of Sri Jayewardenepura, 2022)

Background: Olfactomedin 4 is a glycoprotein encoded by the gene, OLFM4 and found in various tissues including pancreatic β-cells. It involves various pathways of innate immunity, inflammation, and malignancies. However, ...
Evaluation of nutrient agar and Antibiotic Assay Medium 1 as cost-effective alternatives to Mueller-Hinton agar for antibiotic sensitivity testing

Vidana, P. H.; Semasinghe, T.; Kumarapperuma, M.; Ganakarynyan, T.; Saseevan, S. (University of Jaffna, 2024)

The antibiotic sensitivity test (ABST) is a crucial tool in clinical microbiology for determining the most effective antibiotic to treat infections. Though Mueller-Hinton Agar (MHA) is the standard culture medium used for ...
Detection of is6110 (insertion sequence) in serum of Tuberculosis patients reported to kandy chest clinic

Saseevan, S.; Karunathilaka, R.I.S.; Bandara, W.R.U.A.; Madegedara, D.; Arachchi, D. N. M. (South Eastern University of Sri Lanka, 2023)

Tuberculosis (TB) remains a global health challenge, necessitating the development of more sensitive and non-invasive diagnostic tools. This preliminary cross-sectional study explores the potential of detecting the IS6110 ...
Isolation of Streptococcus mutans from dental caries and in-vitro assessment of their antibiotic sensitivity pattern

Wathooth, A.M.A.; Ashra, M.R.F.; Mufeena, M.M.F.; Gnanakarunyan, T.J.; Shamil Mafras, F.S.; Jayatilake, J.A.M.S.; Rajanthi, R.; Thayalini, T. (University of Jaffna, 2024)

Introduction: Dental caries, primarily caused by Streptococcus mutans, poses a global oral health challenge. Early detection of antibiotic resistance patterns in Streptococcus mutans and implementation of effective ...
Antibacterial and antioxidant activity of different solvent extractions of leaves and bark of Erythrina variegata

Thuvaragan, S.; Gnanakarunyan, T.; Bandaranayaka, T.D.; Horshington, A.S.; Fernando, K.M.O. (University of Jaffna, 2024)

Introduction: Plant-based antimicrobials have been proven to be a promising treatment option with several advantages, including fewer side effects and highly diverse pharmacological activities due to secondary metabolites. ...
Teak (Tectona grandis Linn) derived dye: an eco-friendly alternative for Eosin in histological staining

Manage, T.B.M.; Dhanapala, K.M.R. I.; Mahinda, M.T.R.; Rasaratnam, K. (University of Jaffna, 2024)

Introduction: Staining plays a pivotal role in the morphological evolution of tissue samples in histopathology. The combination of Hematoxylin and Eosin is the most common stain utilized for tissue staining. Hematoxylin, ...
The staining ability of natural flower extracts as alternative dyes for bacterial staining

Cafoor, F.N.; Najeem, F.N.; Haseeb, H.F.; Thillainathan, K.; Sivasinthujah, S.; Gnanakarunyan, T. (University of Jaffna, 2024)

Introduction: Gram staining is used as a routine stain in bacteriology. Synthetic stains are commonly used for Gram staining which were reported to cause adverse effects to the environment and user. The use of natural ...
Platelet to Lymphocyte ratio: a novel marker for severity prediction in chronic kidney disease

Azra, M.A.F.; Asra, M.H.F.; Nifla, S.; Brammah, R.T.; Karunaithas, R. (Faculty of Medical Sciences, University of Sri Jayewardenepura, 2023)

Background Chronic kidney disease (CKD) is a progressive loss of kidney function with ongoing systemic inflammation that can be independently predicted by inflammatory markers like Platelet- Lymphocyte ratio (PLR), and ...
Awareness and attitude towards thalassemia among A/L students studying in the Kurunegala Education Zone

Dissanayake, W.M.W.; Sathees, S.; Karunaithas, R. (Faculty of Medicine & Faculty of Allied Health Sciences, University of Jaffna, 2021)

Introduction and Objectives: Thalassemia is one of the most common inherited disorders caused by abnormalities in Hemoglobin synthesis. The successful prevention of the disease depends on the awareness of the general ...
Prevalence of anaemia and its associated factors among the undergraduates of the Faculty of Allied Health Sciences, University of Jaffna

Hennayake, S.H.; Samarakoon, S.A.O.U.; Thennakoon, T.M.B.S.; Sathees, S.; Karunaithas, R. (Faculty of Allied Health Sciences, University of Jaffna, 2023)

Introduction: Anaemia is one of the most common public health concerns worldwide. Although community-based studies are ongoing throughout Sri Lanka, there is a lack of contemporary data on the prevalence of anaemia among ...

Now showing items 1-20 of 33

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