Abstract:
In traditional systems of medicine in Sri Lanka, Artocarpus heterophyllus
Lam., which is commonly known as the ‘jackfruit’ tree (Moraceae) is widely
used to manage the different health conditions which are typically linked to
oxidative stress. Natural antioxidants in plants are able to counteract the
deleterious effects of oxidative stress. Therefore, there is an increasing interest
in employing natural antioxidants as therapeutic agents against different health
conditions. The objective of this study was to compare the antioxidant
activities of methanolic extracts of leaf, bark, fruit and seeds of A.
heterophyllus. For this purpose, DPPH and ABTS assays were carried out by
using a spectrophotometer following standard procedures in which trolox was
used as the standard. Free radical scavenging capacity was determined for
three replicates of each sample extract. Based on the results, the methanolic
leaf and bark extracts showed the highest DPPH radical scavenging activity
(IC50: 112.58±0.25 and 119.94±0.41 mg/ml) while the lowest radical
scavenging activity was detected in methanolic seed and fruit extracts (IC50:
512.65±0.5 and 517.56±0.79 mg/ml) compare with the trolox. The ABTS
activity was higher in methanolic leaf extract (IC50: 124.54±0.22 mg/ml)
while lower values were recorded in methanolic bark, seed and fruit extracts
(IC50: 253.69±0.18, 478.88±0.95 and 525.41±0.89 mg/ml) respectively.
When considering the assays carried out of the methanolic extracts of A.
heterophyllus the following decreasing order was founded: leaf > bark > seed
> fruit. These findings suggest that A. heterophyllus leaves possess the highest
antioxidant properties, and therefore could be used for the production of herbal
medicines in future.
