Abstract:
Introduction: Stauffer's syndrome is a rare paraneoplastic non metastatic hepatic dysfunction related to renal cell
carcinoma. It is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, a-2-globulin, y-
glutamyl transferase, thrombocytosis, prolongation of prothrombin time and hepatosplenomegaly, in the absence
of hepatic metastasis. A rare variant of it with cholestatic jaundice is described in four cases so far in literature.
Clinical presentation: We present a case of a patient presented with features of cholestatic jaundice who was found
to have a left sided renal cell carcinoma in the work up.
Discussion: This case illustrates the importance of considering paraneoplastic syndromes in mind when working
up for patients presenting with hepatic dysfunctions without identifiable causes.
Conclusion: This may result in early identification and intervention which will result in better outcome and
prolong survival rate.
