Solid-phase synthesis of an A-B loop mimetic of the Cε3 domain of human IgE: Macrocyclization by Sonogashira coupling

dc.contributor.author	Spivey, A.C
dc.contributor.author	McKendrick, J
dc.contributor.author	Srikaran, R
dc.contributor.author	Helm, B.A
dc.date.accessioned	2014-02-05T11:55:25Z
dc.date.accessioned	2022-07-11T08:25:20Z
dc.date.available	2014-02-05T11:55:25Z
dc.date.available	2022-07-11T08:25:20Z
dc.date.issued	2003-03
dc.identifier.issn	00223263
dc.identifier.uri	http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/244
dc.description.abstract	The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A-B loop of the Cε3 domain of human immunoglobulin E has been carried out. The key macrocyclization step to form the 65-membered ring is achieved in ∼15% yield via an "on-resin" Sonogashira coupling reaction which concomitantly installs a diphenylacetylene amino acid conformational constraint within the loop.	en_US
dc.language.iso	en	en_US
dc.title	Solid-phase synthesis of an A-B loop mimetic of the Cε3 domain of human IgE: Macrocyclization by Sonogashira coupling	en_US
dc.type	Article	en_US