DSpace Repository

Adaptation of brain functional and structural networks in aging

Show simple item record

dc.contributor.author Lee, A.
dc.contributor.author Nagulan, R.
dc.contributor.author Tuan, T.A.
dc.contributor.author Chen, S.H.
dc.contributor.author Qiu, A.
dc.date.accessioned 2019-10-22T09:03:06Z
dc.date.accessioned 2022-06-27T04:11:17Z
dc.date.available 2019-10-22T09:03:06Z
dc.date.available 2022-06-27T04:11:17Z
dc.date.issued 2015-04-15
dc.identifier.uri http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/1262
dc.description.abstract The human brain, especially the prefrontal cortex (PFC), is functionally and anatomically reorganized in order to adapt to neuronal challenges in aging. This study employed structural MRI, resting-state fMRI (rs-fMRI), and high angular resolution diffusion imaging (HARDI), and examined the functional and structural reorganization of the PFC in aging using a Chinese sample of 173 subjects aged from 21 years and above. We found age-related increases in the structural connectivity between the PFC and posterior brain regions. Such findings were partially mediated by age-related increases in the structural connectivity of the occipital lobe within the posterior brain. Based on our findings, it is thought that the PFC reorganization in aging could be partly due to the adaptation to age-related changes in the structural reorganization of the posterior brain. This thus supports the idea derived from task-based fMRI that the PFC reorganization in aging may be adapted to the need of compensation for resolving less distinctive stimulus information from the posterior brain regions. In addition, we found that the structural connectivity of the PFC with the temporal lobe was fully mediated by the temporal cortical thickness, suggesting that the brain morphology plays an important role in the functional and structural reorganization with aging. en_US
dc.language.iso en en_US
dc.publisher Public Library of Science/PLOS ONE en_US
dc.subject high angular resolution diffusion imaging en_US
dc.subject functional MRI en_US
dc.subject brain Networks en_US
dc.subject Aging brain en_US
dc.title Adaptation of brain functional and structural networks in aging en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record