Please use this identifier to cite or link to this item:
http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11209| Title: | Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors |
| Authors: | Malla, T.R. Tumber, A. John, T. Brewitz, L. Strain-Damerell, C. Owen, C.D. Lukacik, P. Henry Chan, H.T. Pratheesh, M. Salah, E. Duarte, F. Yang, H. Rao, Z. Walsh, M.A. Schofield, C.J. |
| Issue Date: | 2021 |
| Publisher: | Royal society of Chemistry |
| Abstract: | The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some b-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition. |
| URI: | http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/11209 |
| Appears in Collections: | Pharmacy |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Mass spectrometry reveals potential of b-lactams as SARS-CoV-2 Mpro inhibitors.pdf | 2.09 MB | Adobe PDF | View/Open |
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