http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/2 2026-04-20T10:57:21Z 2026-04-20T10:57:21Z Nushrath Roshana, M. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12466 2026-04-20T09:11:20Z 2024-01-01T00:00:00Z

Title: Study of Chemical Components of Herbal Formulation of Neer Perukki Chooranam Authors: Nushrath Roshana, M.; Sathiyaseelan, V. Abstract: The Siddha system of medicine is purely scientific and the peculiar complex system of science and philosophy. Fourier Transform Infrared Spectroscopy (FTIR) is certainly one of the most important analytical techniques for herbo mineral medicine. FTIR can be implemented during herbal drug development in production for process monitoring or in quality control laboratories. The aim of study is to evaluate the morphology and elemental characterization of the Neer Perukki Chooranam. The functional groups of their formulations are analyzed through FTIR spectroscopy and the biological roles of the functional groups are discussed in this study. The raw drugs is collected and purified as per Siddha literature. Drug Neer Perukki Chooranam, which has been illustrated in the Pharmacopeia of Indian Medicine for the management of Neerkattu, Soabai and Makotharam. The Fourier Transform Infrared Spectroscopy compounds show 13 functional groups. There are O-H Stretching (Alcohol), C-H Stretching (Alkane),O=C=O Stretching(Carbon dioxide),C-C bending, (Alkene), O-H bending(Carboxylic acid),C-O Stretching(Aromatic ester),C-O Stretching (Tertiary alcohol), S-O Stretching (Sulfoxide), C-H bending (1,2-disubstituted) and C-1 Stretching (Halo compound) which ensures the therapeutic effect of the drug. The instrumental analysis FTIR study of Neer Perukki Chooranam is the presence of functional groups through the stretch and bends which is responsible for its functional activity. The functional groups in Neer Perukki Chooranam has diuretic activity. According to the FTIR analysis, the research drug "Neer Perukki Chooranam" is very effective for the indications of Neerkattu, Soabai and Makotharam.

2024-01-01T00:00:00Z Nushrath Roshana, M. Nithiakumar, N. Pavithra, K. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12465 2026-04-20T08:57:31Z 2023-01-01T00:00:00Z

Title: Adulteration and Substitution in Siddha Medical System: An Overview Authors: Nushrath Roshana, M.; Nithiakumar, N.; Pavithra, K. Abstract: Siddha Medicine is a system of Indigenous Medicine in Srilanka. Siddha Toxicology (Nanjiyeal) is very important part that is dealt with plant, animal, metal and minerals poison. According the Siddha philosophy everything found in nature has good and bad qualities (Nalvinai and Theevinai). With these ideas Adulteration and Substitution are very important part of Toxicology. Because in 20th and 21 century due to side effects of synthetic drugs, there is an increasing interest in Siddha proprietary medicines. In an International survey, herbal medicines were found to be used by approximately 70% of all over the world to maintain health. The Adulteration and Substitution of herbal drugs is the burning problem in Siddha Medicine and it has caused a major effect in the commercial use of natural products. The deforestation and extinction of many species and incorrect identification of many plants has resulted in Adulteration and Substitution of raw drugs. The future development of analysis of herbs is largely depended upon reliable methodologies for correct identification, standardization and quality assurance of Siddha drugs. Adulteration may be evaluated by Morphological or Organoleptic tests, Microscopic Evaluation, Chemical Evaluation, Physical Evaluation, Biological Evaluation and Analytical methods. This review throws light on the concepts of substitution given by our preceptors and analyses these with the present day prevailing trend of adulteration and substitution.

2023-01-01T00:00:00Z Soruban, T. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12458 2026-04-10T02:56:15Z 2026-01-01T00:00:00Z

Title: Clinical Case Series on Madhumegam (Type 2 Diabetes Mellitus) Management Using the Siddha Herbal Medicine: Keezhanelli Chooranam (KNC) Authors: Soruban, T.; Sathiyaseelan, V. Abstract: According to the 2021 World Bank report, the prevalence of diabetes in Sri Lanka was 11.3% among adults aged 20 -79 years. In Siddha literature, Madhumegam is correlated with Diabetes Mellitus and is classified under Meganoi in Yugi Vaithiya Cinthamani 800, belonging to the Pitha type (Thithippu Neer). Keezhanelli Chooranam (Phyllanthus amarus) is a single-herb formulation documented in the Siddha Pharmacopoeia of India for managing Madhumegam (Type 2 Diabetes Mellitus). To scientifically validate its traditional claim, a clinical study was conducted at the Siddha Teaching Hospital, Kaithady, with ethical approval from the Bandaranaike Memorial Ayurveda Research Institute. Six patients diagnosed with Madhumegam were enrolled. Keezhanelli Chooranam (5 g twice daily before meals with warm water) was administered for 90 days, along with a prescribed dietary regimen. Fasting Blood Sugar (FBS) was measured every 14 days, while Postprandial Blood Sugar (PPBS) and HbA1c were assessed at baseline and on Day 90. Statistical analysis using the paired t-test revealed a highly significant reduction in PPBS (p = 0.008) and a significant decrease in VLDL (p = 0.015). Although reductions in FBS (↓32 mg/dL), HbA1c (↓0.94%), and Triglycerides (↓43 mg/dL) were not statistically significant (p = 0.065–0.068), they indicated meaningful clinical improvement. No adverse changes were observed in Total Cholesterol, HDL, LDL, or Hemoglobin levels. The findings suggest that Keezhanelli Chooranam possesses anti-hyperglycemic and hypolipidemic properties, providing preliminary scientific evidence supporting its Siddha claim in managing Madhumegam. Further validation through large-scale randomized controlled trials is recommended.

2026-01-01T00:00:00Z Soruban, T. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12457 2026-04-09T09:25:37Z 2025-01-01T00:00:00Z

Title: Anti-Bacterial Potential of Siddha Herbo-Mineral Formulation Linga Chenduram: An In-Vitro Study Authors: Soruban, T.; Sathiyaseelan, V. Abstract: Many existing antibiotics have limitations regarding their effectiveness against various pathogens and often cause adverse effects. Overuse of these antibiotics has led to the emergence of drug-resistant microorganisms. The Siddha system of medicine offers promising potential for combating these resistant pathogens. Linga Chenduram (LC), a traditional herbo-mineral preparation mentioned in the ancient Siddha text Anuboga Vaithiya Navanitham, was the focus of this study. The aim of this study was to screen the anti – bacterial potential of Siddha herbo-mineral formulation LC. Anti-bacterial activity of the sample was tested for E.coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) to determine the diameter of inhibition zone (DIZ), minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC). The study results demonstrate that a concentration of 1000 μg/mL of LC effectively inhibited the growth of all tested organisms. The minimum bactericidal concentration (MBC) was determined to be 250 μg/mL. At this concentration, the remaining colony counts were as follows: E. coli (285 colonies, equivalent to 14.2 x 10³ CFU/mL), Pseudomonas aeruginosa (96 colonies, equivalent to 4.8 x 10³ CFU/mL), and Staphylococcus aureus (33 colonies, equivalent to 1.65 x 10³ CFU/mL). The minimum inhibitory concentration (MIC) at which 50% of the bacteria were inhibited (MIC50) was 405.584 μg/mL, 459.61 μg/mL, and 515.575 μg/mL for E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus, respectively. Based on these results, it can be concluded that Linga Chenduram (LC) exhibits promising antibacterial activity against E. coli, P. aeruginosa, and S. aureus. This suggests its potential as a natural alternative or adjunct therapy for infections caused by these pathogens

2025-01-01T00:00:00Z