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Please use this identifier to cite or link to this item: http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/10023
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dc.contributor.authorRohaim, M.A.-
dc.contributor.authorClayton, E.-
dc.contributor.authorSahin, I.-
dc.contributor.authorJulianne, V.-
dc.contributor.authorKhalifa, M.E.-
dc.contributor.authorAl-Natour, M.Q.-
dc.contributor.authorBayoumi, M.-
dc.contributor.authorPoirier, M.C.-
dc.contributor.authorBranavan, M.-
dc.contributor.authorMukunthan, T.-
dc.contributor.authorChaudhry, N.S.-
dc.contributor.authorRavinder, S.-
dc.contributor.authorAmy, B.-
dc.contributor.authorPeter, B.-
dc.contributor.authorHacking, W.-
dc.contributor.authorBotham, J.-
dc.contributor.authorBoyce, J.-
dc.contributor.authorWilkinson, H.-
dc.contributor.authorWilliams, C.-
dc.contributor.authorWhittingham-Dowd, J.-
dc.contributor.authorShaw, E.-
dc.contributor.authorMatt Hodges-
dc.contributor.authorLisa Butler-
dc.contributor.authorBates, M.D.-
dc.contributor.authorRoberto La, R.-
dc.contributor.authorBalachandran, V.-
dc.contributor.authorAnil, F.-
dc.contributor.authorMunir, M.-
dc.date.accessioned2023-12-29T08:15:35Z-
dc.date.available2023-12-29T08:15:35Z-
dc.date.issued2020-
dc.identifier.urihttp://repo.lib.jfn.ac.lk/ujrr/handle/123456789/10023-
dc.description.abstractUntilvaccinesandeffectivetherapeuticsbecomeavailable,thepracticalsolutiontotransit safelyoutofthecurrentcoronavirusdisease19(CoVID-19)lockdownmayincludetheimplementation ofaneffectivetesting,tracingandtrackingsystem.However,thisrequiresareliableandclinically validateddiagnosticplatformforthesensitiveandspecificidentificationofSARS-CoV-2.Here, wereportonthedevelopmentofadenovo,high-resolutionandcomparativegenomicsguided reverse-transcribedloop-mediatedisothermalamplification(LAMP)assay.Tofurtherenhancethe assayperformanceandtoremoveanysubjectivityassociatedwithoperatorinterpretationofresults, weengineeredanovelhand-heldsmartdiagnosticdevice.Therobustdiagnosticdevicewasfurther furnishedwithautomatedimageacquisitionandprocessingalgorithmsandthecollateddatawas processedthroughartificialintelligence(AI)pipelinestofurtherreducetheassayruntimeandthe subjectivityofthecolorimetricLAMPdetection.ThisadvancedAIalgorithm-implementedLAMP (ai-LAMP)assay,targetingtheRNA-dependentRNApolymerasegene,showedhighanalytical sensitivityandspecificityforSARS-CoV-2.Atotalof~200coronavirusdisease(CoVID-19)-suspected NHSpatientsamplesweretestedusingtheplatformanditwasshowntobereliable,highlyspecific andsignificantlymoresensitivethanthecurrentgoldstandardqRT-PCR.Therefore,thissystemcould provideanefficientandcost-effectiveplatformtodetectSARS-CoV-2inresource-limitedlaboratories.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectSARS-CoV-2en_US
dc.subjectDiagnosisen_US
dc.subjectLAMPen_US
dc.subjectPoint of careen_US
dc.subjectArtificial intelligenceen_US
dc.titleArtificial Intelligence-Assisted Loop Mediated Isothermal Amplification(AI-LAMP) for Rapid Detection of SARS-CoV-2en_US
dc.typeArticleen_US
dc.identifier.doidoi:10.3390/v12090972en_US
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