http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/2 2026-04-14T16:43:20Z 2026-04-14T16:43:20Z Soruban, T. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12458 2026-04-10T02:56:15Z 2026-01-01T00:00:00Z

Title: Clinical Case Series on Madhumegam (Type 2 Diabetes Mellitus) Management Using the Siddha Herbal Medicine: Keezhanelli Chooranam (KNC) Authors: Soruban, T.; Sathiyaseelan, V. Abstract: According to the 2021 World Bank report, the prevalence of diabetes in Sri Lanka was 11.3% among adults aged 20 -79 years. In Siddha literature, Madhumegam is correlated with Diabetes Mellitus and is classified under Meganoi in Yugi Vaithiya Cinthamani 800, belonging to the Pitha type (Thithippu Neer). Keezhanelli Chooranam (Phyllanthus amarus) is a single-herb formulation documented in the Siddha Pharmacopoeia of India for managing Madhumegam (Type 2 Diabetes Mellitus). To scientifically validate its traditional claim, a clinical study was conducted at the Siddha Teaching Hospital, Kaithady, with ethical approval from the Bandaranaike Memorial Ayurveda Research Institute. Six patients diagnosed with Madhumegam were enrolled. Keezhanelli Chooranam (5 g twice daily before meals with warm water) was administered for 90 days, along with a prescribed dietary regimen. Fasting Blood Sugar (FBS) was measured every 14 days, while Postprandial Blood Sugar (PPBS) and HbA1c were assessed at baseline and on Day 90. Statistical analysis using the paired t-test revealed a highly significant reduction in PPBS (p = 0.008) and a significant decrease in VLDL (p = 0.015). Although reductions in FBS (↓32 mg/dL), HbA1c (↓0.94%), and Triglycerides (↓43 mg/dL) were not statistically significant (p = 0.065–0.068), they indicated meaningful clinical improvement. No adverse changes were observed in Total Cholesterol, HDL, LDL, or Hemoglobin levels. The findings suggest that Keezhanelli Chooranam possesses anti-hyperglycemic and hypolipidemic properties, providing preliminary scientific evidence supporting its Siddha claim in managing Madhumegam. Further validation through large-scale randomized controlled trials is recommended.

2026-01-01T00:00:00Z Soruban, T. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12457 2026-04-09T09:25:37Z 2025-01-01T00:00:00Z

Title: Anti-Bacterial Potential of Siddha Herbo-Mineral Formulation Linga Chenduram: An In-Vitro Study Authors: Soruban, T.; Sathiyaseelan, V. Abstract: Many existing antibiotics have limitations regarding their effectiveness against various pathogens and often cause adverse effects. Overuse of these antibiotics has led to the emergence of drug-resistant microorganisms. The Siddha system of medicine offers promising potential for combating these resistant pathogens. Linga Chenduram (LC), a traditional herbo-mineral preparation mentioned in the ancient Siddha text Anuboga Vaithiya Navanitham, was the focus of this study. The aim of this study was to screen the anti – bacterial potential of Siddha herbo-mineral formulation LC. Anti-bacterial activity of the sample was tested for E.coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) to determine the diameter of inhibition zone (DIZ), minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC). The study results demonstrate that a concentration of 1000 μg/mL of LC effectively inhibited the growth of all tested organisms. The minimum bactericidal concentration (MBC) was determined to be 250 μg/mL. At this concentration, the remaining colony counts were as follows: E. coli (285 colonies, equivalent to 14.2 x 10³ CFU/mL), Pseudomonas aeruginosa (96 colonies, equivalent to 4.8 x 10³ CFU/mL), and Staphylococcus aureus (33 colonies, equivalent to 1.65 x 10³ CFU/mL). The minimum inhibitory concentration (MIC) at which 50% of the bacteria were inhibited (MIC50) was 405.584 μg/mL, 459.61 μg/mL, and 515.575 μg/mL for E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus, respectively. Based on these results, it can be concluded that Linga Chenduram (LC) exhibits promising antibacterial activity against E. coli, P. aeruginosa, and S. aureus. This suggests its potential as a natural alternative or adjunct therapy for infections caused by these pathogens

2025-01-01T00:00:00Z Prasad, V.M. Sathiyaseelan, V. Velauthamurty, K. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12456 2026-04-09T08:58:27Z 2025-01-01T00:00:00Z

Title: Comparative Phytochemical and Inorganic Ion Analysis of Vellai Vengaya Kulligai: A Siddha Herbo-Mineral Preparation using two ingredient variants Authors: Prasad, V.M.; Sathiyaseelan, V.; Velauthamurty, K. Abstract: With the increasing global recognition of traditional and indigenous medical systems, there is a growing emphasis on the need to standardize and scientifically evaluate the quality of traditional formulations. Vellai Vengaya Kuligai (VVK) is a herbo-mineral formulation in Siddha medicine traditionally used for managing conditions such as Mantham (indigestion), Kazhichal (diarrhea), and Vaayu (pain). Comprising 23 ingredients primarily herbal, with detoxified borax and rock salt VVK holds a prominent place in Siddha therapeutics. Although the term “Vellai Vengayam” suggests the use of white onion, classical Siddha literature indicates the substitution of garlic (Ulli) in its preparation. This study investigates the phytochemical profile of VVK prepared using two methods, one with white onion and the other with garlic and compares their constituents. While white onion is known to contain alkaloids, tannins, phenols, and terpenes, the corresponding VVK tablets were found to have alkaloids, flavonoids, saponins, and terpenes. In contrast, garlic contains alkaloids, phenols, tannins, and saponins, and the tablets prepared with garlic exhibited a broader spectrum, including alkaloids, flavonoids, phenols, tannins, saponins, terpenes, and trace inorganic elements such as iron, nickel, and nitrate. The enhanced phytochemical content observed in the garlic-based tablets suggests greater therapeutic potential as described in classical Siddha texts. This preliminary comparative analysis provides a scientific foundation for understanding the compositional differences arising from variation in preparation methods

2025-01-01T00:00:00Z Soruban, T. Sathiyaseelan, V. http://repo.lib.jfn.ac.lk/ujrr/handle/123456789/12455 2026-04-09T08:22:52Z 2025-01-01T00:00:00Z

Title: Standardization of Keezhanelli Chooranam (KNC): A Single - Herbal Siddha Formulation Authors: Soruban, T.; Sathiyaseelan, V. Abstract: Standardization of herbal formulations is essential to ensure the quality, safety, and efficacy of traditional medicines. This study aimed to establish standardization parameters for Keezhanelli Chooranam (KNC), a Siddha formulation prepared from Phyllanthus amarus, traditionally used in the management of Madhumegam (diabetes mellitus). KNC was prepared according to classical Siddha methods and analyzed using modern techniques in accordance with AYUSH guidelines. Physico- chemical evaluation revealed a brownish, moderately fine powder with characteristic odour, particle size of 94.67 ± 25.5 μm, pH 6.6, and good solubility in water, ethanol, and DMSO. Loss on drying (5.467 ± 0.30%), total ash (0.31 ± 0.026%), extractive values, and absence of acid-insoluble ash were within acceptable limits. ICP-OES analysis confirmed the absence of toxic heavy metals. HPTLC profiling showed multiple phytochemical peaks with Rf values ranging from 0.01 to 0.66. Microbial studies confirmed sterility of the formulation. The results indicate that KNC meets standard quality and safety requirements, supporting its suitability for further pharmacological and clinical evaluation.

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